A Canadian study discovered that extracts from cannabis could affect the ACE-2 receptors in the host cells. ACE-2 receptors are proteins that have been observed to be the “entry points” for coronavirus in the host’s body.
As COVID-19 cases are rising on a severe note, researchers have begun to look for answers in an unlikely place – the cannabis plant. The active compounds found in cannabis have many traits that make it appealing as a possible associate remedy for infections from the unique coronavirus. In such a scenario, the question arises that Will there be CannaCure for COVID-19?
Let’s try to find the answer!
People are questioning if cannabis and CBD can help defencing the immune system against getting COVID-19 in the first place, and if you do understand it, can CBD and cannabis aid heal it?
What about the chance that NSAID anti-inflammatory medicines may have an adverse effect on the virus once you are affected and hold on a —second – CBD is an anti-inflammatory too, so what does that indicate for CBD?
Recently, experts have begun looking at its potential for decreasing sensitivity to the disease, and even debated whether it could be utilized as an antiviral prescription.
According to a study published by Forbs.com, recent reports have implied that severe infection is connected with a cytokine superstorm, which adds to the signs of fever, cough, muscle pain.
These extreme inflammation cases can lead to critical pneumonia, which jams up the lungs and makes breathing painful or impossible.
So, one of the primary approaches that scientists are investigating in the fight against COVID-19 is defeating inflammation.
Particularly, researchers are examining the medicines that decrease the IL-6 cytokine movement. In a modern study, one such medicine, Tocilizumab, was capable of cleaning out patients’ lungs and ended in improvement for 90% of the cases treated.
Sadly, it also unfolded severe adverse side effects like inflammation of the pancreas and hypertriglyceridemia (a risk portion for coronary artery illness).
This has influenced researchers to resume searching for anti-inflammatory approaches – preferably ones that aren’t as rigid on these already critically sick patients.
That’s where cannabis comes in. The authors of that article describe that numerous cannabinoids in the cannabis plant possess anti-inflammatory qualities.
Specifically, they look to CBD as the most suitable applicant for treating COVID-19 associated inflammation. CBD has revealed serious anti-inflammatory traits in early studies.
It doesn’t produce the disorienting psychotropic outcomes linked with cannabis’s most common chemical THC. The FDA has already approved it as safe for kids with obstinate epilepsy.
If successful at decreasing inflammation for COVID-19 patients, it could be a more secure option to other anti-inflammatory alternatives.
Why do researchers think CBD can ease with COVID-19, precisely?
There are several opinions regarding the effectiveness of cannabis for COVID patients, but most of them agree that it might help to reduce the symptoms. Let’s see how.
For one thing, the authors in a research study by Canada, share that earlier research has revealed that CBD can decrease the amount of pro-inflammatory cytokines, including IL-6, the one decreased by other drugs being studied for COVID-19.
CBD was also determined to lessen interleukin (IL)-2, IL-1α and β, interferon-gamma, inducible protein-10, monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, and tumor necrosis factor-α – all of which are linked with the diagnostics of severe instances of COVID-19.
In addition to decreasing these pro-inflammatory cytokines, CBD has also been revealed to boost the production of interferons, a type of signaling protein that stimulates immune cells and stops viruses from replicating.
The research done in the past also promotes the notion that CBD can mainly decrease lung inflammation. In animal research on asthma, CBD was capable of reducing the production of pro-inflammatory cytokine generation, actually decreasing airway inflammation.
In the same research, CBD also lessened pulmonary fibrosis – a state where lung tissue becomes flawed and injured, thickening lung tissue, and causing breathing more challenging.
Want to know more about CBD, See Here!
This is significant because COVID-19 can also leave patients with dangerous pulmonary fibrosis.
The writers also remark that CBD isn’t the only cannabinoid that reveals promise as an anti-inflammatory medicine. THC has also shown strong anti-inflammatory outcomes, but it’s less well endured than CBD, with typical symptoms like disorientation, stress, and increased heart rate.
On the other hand, the analysis of CBD explains it to be harmless and well-tolerated with dosing as much as 1500 mg per day for a time of up to two weeks.
The authors clarify that this “implies its usefulness to overcome SARS-CoV2 induced lung inflammation/ pathology and illness severity.”
Let’s see what recent researches have to say about Cannabis and COVID-19!
Recent Studies on cannabis as a COVID-19 treatment
Scientists from Canada have discovered that extracts from cannabis, also recognized as marijuana, could help stop or manage the coronavirus infection.
The research was published in peer Journal Preprints. The experts conducted it in April, but the results were published in a non-peer-reviewed, preclinical study.
The title of the study was – “In Search of Preventive Strategies: Novel Anti-Inflammatory High-CBD Cannabis Sativa Extracts Modulate ACE2 Expression in COVID-19 Gateway Issues.”
Researchers from Alberta, Canada, led the study. They worked with simulated 3D models of oral, airway, and internal tissues.
High CBD Cannabis Sativa extracts were located to temper ACE2 gene expression and ACE2 protein levels. The results of the study showed that hemp extracts high in CBD might support block proteins – the ACE-2 receptors, which have been discovered as the “entry point” for coronavirus into host cells in the body.
Let’s understand some of the glimpses of that research!
With the fast-growing pandemic of COVID-19 induced by the new and challenging to tackle zoonotic SARS-CoV2 coronavirus, there is an essential requirement for new treatments and prevention tactics that can help reduce disease spread and lessen mortality.
Restraint of viral entry and through spread constitute plausible healing avenues. Similar to other respiratory pathogens, SARS-CoV2 is transferred through respiratory droplets, with potential for aerosol and touch spread.
It utilizes receptor-mediated entrance into the human host body by angiotensin-converting enzyme II (ACE2) that is dispatched in lung tissue, as well as oral and nasal mucosa, kidney, testes, and the gastrointestinal region.
The inflection of ACE2 levels in these gateway tissues may demonstrate a believable policy for reducing disease susceptibility.
Cannabis Sativa, particularly one high in the anti-inflammatory cannabinoid cannabidiol (CBD), has been suggested to change gene expression and inflammation and refuge anti-cancer and anti-inflammatory qualities.
Working under the Health Canada research license, they have acquired over 800 new cannabis Sativa varieties and extracts and hypothesized that high-CBD C. Sativa extracts could be utilized to modulate ACE2 affect in COVID-19 target tissues.
With reference to this research paper, Dr. Igor Kovalchuk (University of Lethbridge) explains it this way:
As with the examination into nicotine’s impact on the coronavirus, it is thought that some strains of cannabis decrease the virus’s capacity to invade the lungs, where it takes grasp, multiplies, and spreads.
In a document on preprints.org, where experts can write non-peer-reviewed results, Kovalchuk and associates write that their uniquely cultivated strains of cannabis efficiently stop the virus from infiltrating the human body.
The study is one of many research papers worldwide that have been published on preprint websites, including preprints.org, to broadcast initial verdicts into potential COVID-19 therapies that have yet to undergo severe peer review.
The coronavirus requires a “receptor” to access a human host. That receptor is identified as an “angiotensin-converting enzyme II” or ACE2.
ACE2 is located in lung tissue, in oral and nasal mucus, in the kidneys, testes, and gastrointestinal tracts, they write.
And the hypothesis is that by modulating ACE2 levels in those “doorways” to the human body, it may be feasible to lower our susceptivity, or vulnerability, to the virus. It might primarily reduce our chance of infection.
Let’s see what Israeli researchers from The Medical Cannabis Research and Innovation Center have to say on this:
Dr. Igal Louria-Hayon, with his team from The Medical Cannabis Research and Innovation Center at Haifa’s Rambam Health Care Campus, is conducting an analysis of cannabis and COVID-19 connection.
This research implies the effects of medical cannabis could be utilized as a means for handling some symptoms of severely sick COVID-19 patients.
Contemporary research shows that when the body’s immune system identifies a new and dangerous invader, a large number of white blood cells are stimulated and release inflammatory “communication molecules” named cytokines, which initiate even more white blood cells and improve the inflammation process, Dr. Igal Louria-Hayon unfolds.
This storm of cytokines might result in the out-of-control inflammatory response, which can worsen the sickness and can also lead to death.
Dr. Louria-Hayon stated that, based on their preliminary data, they hypothesize that cannabis may modify the cytokine storm, which happens during COVID-19 disease.
Their purpose is to use cannabis therapy to downregulate the inflammation storm before the patients manifest critical lung infection.
Active elements in cannabis initiate an internal system in the body named the endocannabinoid system. Since the body usually creates and uses substances similar in form to the active ingredients of cannabis, it can also react broadly to the cannabis plant itself.
“We hope that by decoding the cannabinoid activity mechanism during inflammatory storms, we can treat COVID-19 patients where conventional drugs have failed.” – Dr. Louria-Hayon
Moreover, he also said that their cannabis treatments’ uniqueness is based on their perception of the mechanisms of cannabinoids movement and scientific conclusions.
This trial will begin in the next few months. Based on its report, they will proceed to the second clinical research, where they will treat COVID-19 patients with the candidate strains of cannabis that displayed anti-inflammatory potential on human-derived cells.
Risks of cannabis usage during the pandemic
However, those who believe in increasing their cannabis consumption to prevent or heal COVID-19 infection should take these initial results with a significant bit of salt!
Particularly, smoking more marijuana is likely to put users at higher risk of disease.
As for those questioning if edibles or oils are a more secure option, there just isn’t enough analysis to prove these goods are genuinely efficient against COVID-19 either.
With contemporary research on cannabis as a COVID-19 restraint and therapy policy still in the very initial stages, it will likely take some time before the researchers have a definite answer as to whether these products are reliable and effective choices.
All the information mentioned above doesn’t indicate that cannabis might be viewed as a cure or treatment of COVID-19 on its own.
It does imply that it may have the potential to support bring down inflammation and decrease anxiety in those undergoing the disease. But until more investigations are made, this is just a well-supported hypothesis.
Hundreds of people have shared reports referencing cannabis as a remedy for coronavirus, but some of the titles have been misleading.
There are undoubtedly many trials taking place globally, including in Canada, Israel, and the UK, examining whether cannabis could be beneficial as a medication.
Medicinal cannabis has been proven to reduce inflammation. So, it could possibly be used to handle cytokine storms – the critical immune response sometimes seen in the most delicate Covid-19 patients.
But these experiments are at a rather early stage, so it’s too early to come to any judgments about whether cannabis will establish an effective remedy against coronavirus or will there be CannaCure in the future.