Cannabis, the drug also goes by the name marijuana, has gained a curiosity in recent times for its potential value as an antiepileptic substance. Explore this post to learn how medical marijuana can decrease the adverse effects of seizures (or epilepsy). Also, have a glance at the best medical marijuana strains for seizures.
The two main elements of marijuana are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). The delta-9-tetrahydrocannabinol has had mixed results in epilepsy, wherein cannabidiol has been showing more uniform antiepileptic effects. Data establishing the use of medical marijuana for this disorder are limited, as most trials were conducted before 1990. Case reports are conferring promising results; however, we cannot depend on the consistency of the data we cannot generalize it. The legal concerns in the globe also may restrict the application of medical marijuana as an antiepileptic.
Epilepsy is repetitive and ongoing seizures caused by changes in neuronal firing in the brain. Nonepileptic seizures are not allied with neurophysiological changes. 3% of the populace is predisposed to epileptic seizures. Current pharmacotherapy for epilepsy aims to reestablish neuronal capacity and decrease seizure recurrence. Prospective, randomized experiments conclude that individuals experiencing a first, unwarranted seizure have a 40% to half possibility of seizure repeat at two years.
The risk of repeat, which diminishes with time, is highest quickly following the first seizure, with 80% to 90% of patients experiencing repetitive seizures within the first two years. Despite available treatments, about 30% of patients stay resistant to therapy, resulting in poorly controlled and recurring seizures. This review discusses the ebb and flows of research on the method of reasoning for and limitations to the use of marijuana to treat seizure disorders.
Historical Usage of Medical Marijuana
The earliest archived use of cannabis occurred in around 2,700 BC in China. It was useful for an assortment of clinical ailments, including gout, intestinal sickness, constipation, menstrual disorders, and absentmindedness. Western medication received the use of medical marijuana as a common analgesic in the nineteenth century. Cannabis strains were accessible in the US pharmacies as an OTC product until the Marihuana Tax Act of 1937 restricted its accessibility.
Consequently, the grant of the Controlled Substances Act in 1970 proffered medical marijuana a Schedule-I class, making its usage illegal. Since 1970, there has been a rising interest in applying marijuana for its possible antiepileptic qualities.
Medical Marijuana Strains and Pharmaceutical Science
Cannabis Sativa and Cannabis Indica are two varieties of plants. Both of these varieties have a long history of effectiveness as antiepileptic. Moreover, Sativa strains produce more psychotropic and stimulating effects, and Indica strains produce more sedative effects. Compounds held in the medical marijuana strains are known as cannabinoids. Cannabis comprises two main components: the psychoactive delta-9-tetrahydrocannabinol (THC) and the nonpsychoactive cannabidiol (CBD).
The type-1 receptors do the job here to make the connection between cannabis and seizures. The presence of cannabinoid type-1 receptors in the hippocampus and amygdala makes cannabis an attractive agent for epilepsy, the two connected with deficient seizures. The THC segment of cannabis is a fractional agonist at these receptors.9 Conversely, CBD interacts with other nonendocannabinoid signaling systems, reducing THC’s psychotropic activity while increasing tolerance. Recent tests of CBD have revealed more compatible anticonvulsant characteristics, and this cannabinoid has gained curiosity as a possible agent for epilepsy. There are numerous potential administration routes for synthetic CBD. The first non–delta-9-THC phytocannabinoid assessed for its anticonvulsant effects in clinical trials.
The most widely recognized delivery course is by inward breath, either recreationally or for therapeutic purposes. Because of CBD’s highly lipophilic nature and its high volume of distribution, the lungs are a practical course of prescription delivery, with quick distribution into the brain, adipose tissue, and organs. Cannabinoids are widely utilized by the liver, mainly by CYP3A2, CYP3A4, CYP2C8, CYP2C9, and CYP2C19. Owing to the first-pass metabolism through the liver, CBD is approximately 6% bioavailable, hence rendering oral, oral-mucosal, and sublingual delivery methods less acceptable.
The transdermal passage of administration has also been there; however, this course might be economically impractical, since one of a kind delivery systems are expected to forestall excessive aggregation of CBD in the skin.
Side Effects of Treating Seizures and Epilepsy with Marijuana
Clinical trials examining the adequacy of marijuana for treating epilepsy are limited. Probably the earliest was a small randomized, controlled study directed by Mechoulam in 1970. In this case, nine subjects with treatment-resistant temporal lobe epilepsy took either CBD or placebo for five weeks, along with antiepileptic therapy. Two out of four CBD patients were seizure-free at a 3-month development, whereas none of the five placebo patients showed improvement. However, this preliminary was limited by its small sample size and absence of statistical analysis or power count.
Cunha and colleagues directed a small randomized, controlled preliminary involving 15 patients with generalized epilepsy. Seven patients got CBD, and eight got a matching placebo for 3 to 18 weeks. There were no recorded toxicities, and four CBD patients matched with just one placebo patient were seizure-free. This research was limited because it had no performed power figuring, no analytical interpretation, and used a small sample.
Although several controlled studies demonstrated some viability of CBD for epilepsy, more ongoing studies indicate that CBD has narrowed or no effect on epilepsy. In one preliminary, Trembly and Sherman inspected the effect of marijuana on uncontrolled epilepsy. The research found no overall discernible effect, and there was no statistical analysis of preliminary outcomes or principle effects. A study led by Ames and Cridland showed no difference between CBD and placebo. As was the case in earlier tests, the study populace was small, and there were no power calculations.
Various case reports have identified grown-up patients favoring marijuana as antiepileptic treatment, and parents who have tried marijuana with CBD content to manage resistant epilepsy in their children. Some of these records produce promising data. However, there is no representation of dosage, description, course of conduct, or span of medical marijuana therapy.
The placebo effect and recall bias might be confounding variables. These limited case reports highlight an absence of safety and adequacy information from randomized, controlled trials to confirm the use of cannabis for the treatment of epilepsy. Check the image-1 for a summary of studies on cannabinoid application as an antiepileptic agent.
Adverse Effects of Cannabis Usage
Adverse effects of constant marijuana use incorporate habit risk, negative effects on brain advancement, increased risk of certain psychological sicknesses, engine vehicle accidents, and various health effects. Diagnostic and Statistical Manual of Mental Disorders (DSMMD) unveils that 9% of people who utilize medical marijuana may get addicted. Besides, discontinuation of regular cannabis use may cause withdrawal symptoms such as cravings, irritability, insomnia, and nervousness.
Cannabis admission at a young age may affect brain improvement, as it can debilitate neural connectivity in particular areas of the brain, resulting in remodeled learning, memory, and capacity. Marijuana use in adolescence could prompt a heightened response to other drugs, paving the route for addictions to other drugs in adulthood. Consistent marijuana use relates to tension and depression; however, a causal relationship is not accessible. There may also be a definite relationship between marijuana smoking and an increased frequency of lung cancer and other pneumonic illnesses, through lung aviation route aggravation, aviation route resistance, and hyperinflation.
Heavy and constant marijuana use may incite most of the adverse effects, mostly attributable to the THC part. However, there may also be puzzling variables; hence, the causality report is not accessible. Prospective studies of CBD may emerge in a different side-effect outline. Different small studies of CBD safety in humans have shown satisfactory resistance with no notable side effects at a dosage up to 1,500 mg daily by mouth or 30 mg IV when used intensely and chronically.
Legalized Medical Usage of Cannabis
While 33 US states have approved medical marijuana, the other 17 states have all passed bills supporting the use of CBD (cannabidiol) extract, commonly in oil form, with minimum THC (tetrahydrocannabinol), and often for the remedy of seizures and epilepsy in severely sick children. Besides, Massachusetts allows marijuana for conditions as decided in writing by a qualifying patient’s physician. Canada, along with the Netherlands and Israel, allows the use of medical marijuana.
Future research involving drug products of cannabis or synthetic substances that act like cannabis must be precisely utilizing an Investigational New Drug Application before human trials. Besides, the DEA (Drug Enforcement Administration) examines the researcher’s application. Also, the National Institute of Drug Abuse is prone to deliver research on medical marijuana for experiments. Eventually, for a drug product to get legal for the US advertise, the FDA must ensure that it meets the necessary quality standards and is safe and productive.
Top 10 Best Cannabis Strains for Seizures and Epilepsy
Cannatonic created a generally light and smooth high that doesn’t last long as other strains, but it is enjoyable for precisely that reason as well. This strain doesn’t make you feel lazy but instead allows you to feel like you are lighter after dumping all of the burdens on your shoulders. This hybrid makes you feel relaxed and confident, floating on a dreamy haze of happy feelings. Cannatonic allows you to feel motivated without the increase of energy; it is a lot more quiet, more soothing sort of high that will make you smile wildly in a constant state of feeling thrilled.
Cannatonic induces a composed high that can increase your focus and push you to sort your thoughts, slowly making a judgment of any ideas you may have. This bud will make you need to be more productive with your day, and it will encourage you to stay in a constant state of pleasure while being productive.
One strain that can efficiently alleviate discomfort is ACDC. It is a famous strain with high CBD material; that’s the favorite of patients suffering from IBS’s chronic pain and also discomfort. It is a Sativa-dominant strain and a phenotype of Cannatonic. It implies that it is medical marijuana with extremely little to absent psychedelic results. ACDC has a THC: CBD balance of 1:20 with THC at approximately 19%. You can practice ACDC to overcome conditions like tension and depression with its all-natural mood-enhancing impacts. It’s a good anti-seizure strain that may help to manage headaches, chronic pain, back pain, and much more.
Treating epilepsy, seizure disorders, Dravet syndrome, IBS, or other inflammatory conditions with ACDC can be proven revolutionary. You can additionally depend on ACDC for the alleviation of physical and also psychological tiredness. Like other medical strains, ACDC may cause red eyes, small paranoia, and cottonmouth. These adverse effects could be kept minimum by consuming this weed in a modest dose.
3 – Charlotte’s Web from Sensible Seeds
Charlotte’s Web is one of the best medical marijuana strains that may treat Dravet syndrome without side effects. Charlotte’s Web is a Sativa-dominant cannabis strain that contains higher levels of CBD. What makes this strain novel is that it got its name after Charlotte Fiji, a young girl suffering from Dravet Syndrome, which causes her to have several seizures every day.
Charlotte’s Web turned into the focus of an across the country exertion to make clinical marijuana legally accessible for epileptic patients like Charlotte. Charlotte’s Web is mostly Sativa. However, because of the absence of THC focus in the strain, possible psychedelic effects are negligible to none. Strains that have a high CBD to THC ratio, Cannabidiol CBD, or CBD oil may help as an anti-seizure element.
Some users would describe its effects to focus mostly on the physical. Thus, users generally feel more relaxed after intake. The Sativa effects of Charlotte’s Web provide an overall improvement in a user’s disposition that also provides happy feelings, focus, and oozing energy. With an astounding CBD fixation that can reach as high as 17%, Charlotte’s Web is an ideal substitute for those who suffer from specific health conditions.
4 – Ringo’s Gift from Canadian Hemp Co
Ringo’s Gift is an additional therapeutic strain named after Lawrence Ringo, a cannabis activist, and a CBD advocate. The strain is a CBD-dominant weed made by incorporating a Harle-Tsu and ACDC. Ringo’s Gift offers analytical stimulation and also relaxation. You will undoubtedly love its beautiful, earthy, and also flowery tastes, which will undoubtedly make you return for more. Ringo’s Gift features a CBD of 15.8% as well as 0.6% THC. This high CBD is among the reasons it is a part of the food selection of popular coffee bars in the Netherlands. With Ringo’s Gift, you’ll get a mix of cerebral activity and healthy relaxation without side effects. Ringo’s Gift is a good anti-seizure strain that may help to manage headaches, chronic pain, back pain, and much more.
This crossbreed is known to treat swelling, consisting of IBS signs and symptoms. You can finish pain like belly pains, frustrations, migraine headaches, arthritis, chronic discomfort, muscular tissue pains, and strains. You can use Ringo’s Gift to quit anxiety and clinical depression because it is uplifting and loosening. If you have had trouble sleeping, this strain can additionally aid you out. It can stop sleeping disorders and insomnia and get that good night’s sleep with Ringo’s Gift. Ringo’s Gift is one of the best medical marijuana for seizure disorders.
The White Widow medical marijuana is reasonably the most famous and notable marijuana strain out there. White Widow is usually the first marijuana strain that most individuals attempt. Hence, it makes sense that such a significant number of individuals go to it to help them with neuropathy. The thing that makes this strain so great is its monstrously high THC levels. THC at 25%, this strain is easily one of the strongest on the planet.
The ‘high’ of White Widow leaves you revitalized, yet somehow still super relaxed and relaxed. This strange blend of sensations makes it ideal for getting you through awkward pains. It makes you painless, but you will also feel comfortable, quiet, and excited about your general surroundings. Stunningly better, it doesn’t cause any tiredness, as such a significant number of other potent Indica strains, so it’s ideal for daytime use. It is an incredibly even strain that makes those suffering from neuropathy feel like their concern is a thing of the past.
The main potential issue is that it is easy to accidentally smoke an excessive amount of White Widow without a moment’s delay, potentially bringing on some powerful feelings of tension or suspicion. The most reliable way to keep away from this strain is to go slow with a moderate dosage.
Earning itself the much-deserved title of one of the most mainstream Sativa around, Green Crack produces a powerful head-high. It is euphoric, and the ‘high’ mixed in with a sense of being relaxed is among its most excellent traits. If you are seeking a lift of energy rapidly in the day, Green Crack can give that without the feeling of a substantial body. For anybody looking to inspire and boost creativity, Green Crack is a perfect marijuana strain.
It enables the user to stay concentrated while having a general vibe good state of mind with a boost of energy. Numerous individuals pick Green Crack as a day-starter – regardless, replacing their sturdy mug of coffee with it. The energetic, cerebral effect Green Crack provides, is for enhancing focus. It is the reason it is famous for quite a long time when you need a little boost to finish your tasks, such as running errands, building, or cleaning. Another effect is that Green Crack causes a feeling of the hunger strike; it’s an attractive trait that adds to its popularity.
7 – CBD Chronic from Dinafem Seeds
CBD Chronic is a cross strain between CBD Crew and Serious Seeds. It arises from the well-known Chronic strain, a therapeutic strain with high CBD content. The overall ratio of THC-CBD provided by this plant is 1:1. The sample with the most potent overall amounts claimed 7.88% THC and 6.93% CBD. Same as the original Chronic strain, CBD Chronic is very easy to grow. Besides, it’s one of the strains that beginners can try without side effects.
It is a weed strain that first gets trials into therapeutic research. The high-CBD strain is useful for extracts such as ointments, cremes, lotions, and CBD oil. CBD Chronic is a good anti-seizure strain that can also be used to manage headaches, chronic pain, back pain, and much more.
This dominant hybrid is a great smoke when you are looking to find some psychological release, without feeling exhausted. Harlequin has received all its positive results from its origin. This strain is a remarkable relaxant, with an ability to quiet the mind and stay focused.
Harlequin is uplifting and a happiness-inducing weed. This Sativa-dominant cannabis will let you keep your productivity at 100 percent without side effects. It means that it’s the ideal smoke to start a day with, because instead of slowing you down, this strain may assist you with getting stuff done, and get it done while feeling inspired and creative. Harlequin is excellent at keeping you focused and will let make them complete your usual tasks with more exactness and vigor.
Because GDP is a classic Indica, it can make an intense mental high, leaving you to quiet down and generate a fresh brain buzz. For those seeking a profound and relaxing recreational high, Grand Daddy Purple offers just that without side effects. It is a powerful sleep-help, which makes it the ideal nighttime puff.
Not only does it assist you with unwinding and let go of all your stresses, but it also leaves you feeling happy and content. It is what makes it an excellent ally for a warm air pocket shower toward the day’s end. A sense of rapture is one of the effects of Grand Daddy Purple. And, it renders a sense of happiness, and a strong desire to laugh. Sometimes, GDP can encourage a voracious appetite but isn’t present in each user.
10 – Romulan from Seed Supreme
If you are looking to be fruitful on this strain, you should go for it. This potent Indica will make you succumb to gravity without even a trace of an opportunity at fighting it. Its ‘high’ can deliver a substantial body with a guaranteed lounge chair lock – so it is fully appreciated when you can hit back and relax.
This strain will make you sense that you are in a full body massage, just as you’re lying down. Romulan is an ideal relaxant, really undoing the knots in your back and making you have an inclination that you are floating on a cloud in a dense brain haze. If you continue smoking, you may get sleepy, which makes for the ideal nighttime smoke altogether.
It will mitigate your negative thoughts and make you feel floaty. You will feel relaxed and hungry, which can make you comfortable without side effects.
Firstly, there is inadequate data to form a reliable conclusion about the effectiveness of marijuana as an antiepileptic agent. Notwithstanding case reports showing effectiveness in decreasing seizure recurrence and severity, there are insufficient clinical studies on its suitability for this implication. Secondly, the studies carried out were insufficient, lacked comprehensive information, and used small sample sizes. There are some researches on the long-term treatment of cannabis and its safety outline.
In recent times, legal limitations on cannabis make it complicated to carry out large-scale clinical experiments. Even the FDA has listed marijuana as a Schedule-I controlled substance. Therefore, we cannot ascertain the efficacy of cannabis for the therapy of epilepsy presently. More large-scale study results should be available that evaluate the potency and safety of cannabis administration with either high CBD-THC ratio cannabis or separate CBD composites.
- 1 Historical Usage of Medical Marijuana
- 2 Medical Marijuana Strains and Pharmaceutical Science
- 3 Side Effects of Treating Seizures and Epilepsy with Marijuana
- 4 Adverse Effects of Cannabis Usage
- 5 Legalized Medical Usage of Cannabis
- 6 Top 10 Best Cannabis Strains for Seizures and Epilepsy
- 6.1 1 – Cannatonic from ILGM
- 6.2 2 – ACDC from Crop King Seeds
- 6.3 3 – Charlotte’s Web from Sensible Seeds
- 6.4 4 – Ringo’s Gift from Canadian Hemp Co
- 6.5 5 – White Widow from ILGM
- 6.6 6 – Green Crack from ILGM
- 6.7 7 – CBD Chronic from Dinafem Seeds
- 6.8 8 – Harlequin from ILGM
- 6.9 9 – Granddaddy Purple from ILGM
- 6.10 10 – Romulan from Seed Supreme
- 7 Final Verdict