Top 10 Best Cannabis Strains for Migraine – Ease Your Headaches Quickly

Studies have shown that medical cannabis might help fight severe medical conditions such as various types of disease and give significant pain relief to patients suffering from an extreme and interminable pain condition. Read this article to explore the best cannabis strains for migraine and headache, and understand how medical cannabis helps in this severe condition.

When we think of the best medical marijuana strains for migraines, the finest strain that can keep your headaches in check is the White Widow cannabis strain; visit the official website to buy pure seeds.

Individuals have been turning to cannabis as a type of pain relief for as long as humans first started consuming the plant countless years ago. Cannabis can be an efficient remedy for treating numerous different medical issues and is exceptionally well suited for treating non-life-threatening conditions such as migraine (headaches). 

Even though we always advise seeking professional medical advice when using medical cannabis as a treatment for a medical condition, cannabis has consistently garnered distinction in treating headaches. 

Usage of Medical Cannabis for Migraines


best marijuana strains for migraine

These days, nobody can bear to let a disease like a migraine slow them down. It includes balance troubles, nausea, sensitivity to light, sensitivity to sound, disorientation, and blurred vision. Medical cannabis could be a workable treatment alternative for some ailments, including migraines. However, at present, research is still being continually done to treat these pains. Is Sativa or Indica better for migraines? Please continue exploring to uncover more about the topic.

What Triggers Migraines?

One thing to note is that every sufferer experience migraine differently. A migraine you have can be altogether different from how other people encounter them. Even sensitivity to light may cause headaches to many people.

Individuals who suffer from migraines can often identify specific migraine triggers. 


These can be seasonal or even allergic reactions. 

Irregular Environments:

It can incorporate bright lights or loud noises. Gathering lights and even strong smells can trigger migraines. 


It can be any stress. Examples incorporate business-related, depression, tension, and even physical stress. 


Tiredness, stream lag, or irregular sleep would all be able to prompt migraines. 

Change of Diet:

Some migraine sufferers say that when they skip dinner, overeat, or have a little something (nuts, chocolate, etc.), it triggers a migraine. Specific foods that contain tyramine (smoked fish, beans) or nitrates (salami and bacon) are also known to trigger the pain. 

Research on Cannabis for Migraine Treatment

Numerous studies suggest any headaches, including migraines, can be eliminated by medical cannabis consumption. Medical research has used the number of the plant’s components and an assortment of formulations like pills, fluid, and fume. 

One of the most significant studies includes 121 adult migraine patients. The researchers used marijuana medications with inhalations and edibles. Out of them, 85% have recorded a drop in migraine recurrence. Furthermore, 11.6% of them felt the improvement in intense attacks and side effects. The most well-known side effect was the feeling of tiredness or exhaustion. 

There have been more studies looking at how effective medical cannabis can be against ceaseless pain. According to such analyses, medicinal marijuana and cannabinoid extracts improve the pain thresholds and give relief. 

Furthermore, in a review of 38 published randomized controlled trials, 71% found that cannabinoids demonstrated a significant pain-relieving effect. In the same study, 91% of patients used medicinal cannabis as an intense and persistent treatment for migraines. 

Result of Cannabis Treatment for Migraines

The following is a report of late research summarized in a published study: 

Image: A clinical report showing the effects of cannabis as a treatment for headache

The substance classification of cannabis has dramatically restricted large scale research investigations. Moreover, we can expect large scale randomized and placebo-controlled studies to demonstrate clinical observations and initial findings. 

Besides, the current Schedule-1 classification of cannabis makes it incredibly difficult. As a result, proof for cannabis-based migraine (headaches) treatment is more limited to several smaller recounted reports, case studies, and surveys. 

How Cannabis React to Migraines

The human body consistently creates endocannabinoids, and it has corresponding receptors in the cerebrum. Once the cannabinoids bind with receptors, some cannabis components augment the effects. 

Furthermore, some components work as antagonists that inhibit the effects. There is proof that cannabinoids may reduce irritation and diminish the sensation of pain, and CBD is the segment accepted to regulate these results. There are many medical strains for migraines available in the market.

Core Components of Cannabis

Cannabis is famous for its two major components, Cannabidiol (CBD) and Tetrahydrocannabinol (THC). Both of these can actuate numerous effects that can help medicinally. THC is ordinarily associated with the general feeling of being high and a state of happiness. CBD slows down mental activity and helps you feel relaxed. 

Indica or Sativa? Which One is Better for Migraines?

There are two primary subspecies of cannabis: Indica and Sativa. Among these two, Sativa contrives high THC levels and low CBD levels. Consequently, it tends to produce more uplifting, dynamic, and euphoric effects. Thus, Sativa is mostly useful during the daytime. 

Then again, cannabis Indica has a moderate THC level and extremely high CBD levels. It gives more calming, relaxing, and soothing qualities. Indica conveys more sedative effects and might be more proper for use at night as it can bring drowsiness.

Ways of Ingesting Cannabis


It is a traditional model of cannabis consumption. It produces the fastest onset and sedative effects. Smoking weed produces carcinogenic substances, prompting aspiratory and lung issues. As a result, experts often prescribe healthier alternatives to use medicinal cannabis. The effects will not last for the long term but it renders quick euphoria or sedation, depends on the type of weed.


Vaporizing has been emerging as a trending way of having cannabis. A vaping pipe is similar to an e-cigarette that heats the weed. Thus, you can inhale cannabinoid vapors without overheating. It causes smoke and respiratory toxins. Furthermore, it eliminates the messy piece of smoke. Vaping has a quick onset, such as smoking. 

Oils or tinctures:

It can carry cannabis through oil that if you place it under the tongue. It’s a comparatively safe consumption method than smoking and vaporizing.


Sprays can also be useful in cannabis consumption. Cannabis can be blended into a fluid and used in nasal sprays or mouth sprays. 

Topical formulations:

A lotion or cream that is applied straight to the body’s surface. It is useful for fast-acting relief of pain. Cannabis topicals usually are non-intoxicating, enabling patients to have the plant’s healing effects without experiencing psychoactivity. This growing section of cannabis medicines has developed to introduce transdermal solutions. Some lubricants often combine essential oils such as wintergreen and clove for further relief.


You can also blend cannabis in with a variety of foods. Healthy foods incorporate candy, brownies, and other baked stuff. However, you should take care as the effect is typically different. It can take one or two hours before you notice side effects. Secondly, it is also can be more intense when ingested, and the sedative effects can last longer.


You can also blend cannabis in with tea or some other drinks. That way, you can also have your preferred taste while consuming cannabis. 


It can contain cannabis and help control the dose when made by an accredited manufacturer. You should also take advice from your doctor about the dosage before using any pills.

Cannabis is the most effective substance if you sedate when the headache starts before an all-out migraine begins. Here are some of the top strains for migraines and headaches.

Best Cannabis Strains for Migraine

Medical cannabis strains require anti-emetic and anti-inflammatory properties to get in the list of best strains, targeting more specific migraine (headaches) symptoms. Do you want to explore it further? Read on to discover the best cannabis strains for migraines.

#1 – White Widow from ILGM Seed Bank


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White Widow is a Sativa-dominant hybrid strain that is famous for its energizing effects. Though this strain is not as well-known for the flavor, migraine sufferers use it for its high cerebral effects, migraine relief, and pain relief. 

Most users say that they become more conscious of their surroundings after having this strain. They felt tuned into sounds and patterns that some might not usually notice. White Widow holds around 19%  THC and CBD content remains low.

Enthusiasts also describe an almost quick uplift in the energy and disposition that can help boost your focus. Numerous individuals are fans of using this for relieving migraines, fatigue, and depression. Overall, it’s one of the best strains for migraines.

#2 – ACDC from i49 Seed Bank


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The ACDC Sativa-dominant strain has all the substances to improve your mood that can also bring migraine relief. It indeed works in migraine as it has a super high CBD content. Overall, it’s one of the best medical marijuana strains for migraines.

Sativa-dominant ACDC can assist with many medical conditions like migraine, headaches, tissue pain, MS, and PTSD. All with almost no psychoactive effect. However, there is a medicinal cannabis community whose sole purpose is to mend the body and brain with no psychoactive effects. It is one of the top high-CBD anti-inflammatory strains for migraines.

Such medical strains are a reasonably new development in the medical marijuana industry. They just started gaining traction once individuals understood that high levels of CBD content could create profound therapeutic results, with virtually no high. Numerous individuals have been requesting breeders to develop strains with a high percentage of CBD for these specific goals. 

#3 – Harlequin from ILGM Seed Bank


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Harlequin is a famous CBD-heavy strain whose popularity originated from its healing effects. It is a product created from Colombian Gold, Nepali Indica, Thai, and Swiss Sativa.

Furthermore, it is around 75% Sativa and holds 4 to 10% THC content and 6% to 15% CBD content, making a CBD-THC ratio of nearly 2:1. Harlequin is known to bring painful condition at ease in migraine sufferers without psychoactive effects. It can relieve chronic pain associated with stiffness and joint and also give migraine relief.

It also has powerful mitigating properties that are valuable for fibromyalgia and chronic pain. Besides, this strain also permits users to have a sustained mental focus. Overall, it’s one of the best cannabis strains for migraines.

#4 – OG Kush from ILGM Seed Bank


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The OG Kush is one of the best strains, well-known all over the world for migraine sufferers to ease the pain. Moreover, OG Kush is a cross genetic strain between the Hindu Kush and the Chemdawg. With a high THC-CBD ratio, it holds up to 27% of THC content that can give you migraine relief. Apart from that, Northern Lights is another Indica-dominant medical marijuana with high levels of THC that may help chronic migraine pain.

The cerebral effect that the OG Kush strain provides is more focused on the mind of migraine sufferers. It is a versatile smoke that allows users to intensify their mindset. Overall, OG Kush is one of the best medical marijuana strains for migraines.

OG Kush can diminish uneasiness and depression because it allows individuals to live at the time. Numerous individuals have demonstrated how much it helps fight against headaches and migraines. It is also useful for a loss of appetite and nausea.

#5 – Purple Kush from ILGM Seed Bank


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Individuals always told to sleep to get migraine relief. Well, that is easier said than done with Purple Kush. When migraines keep you from getting your essential rest and sleep, Purple Kush is an ideal variety to get an Indica-heavy cannabis strain. Northern Lights is another great strain to smoke if migraine sufferers crave high THC content. Northern Lights cannabis holds nearly 18% THC that can induce sleep.

With a high THC-CBD ratio, Purple Kush is a pure Indica cannabis strain having 17 to 22% of THC content. Moreover, it has 0.07 to 0.01 percent CBD. Besides, it provides a soft numbing feeling, relaxation, and a night of rejuvenating sleep. With just a trace of Purple Kush, there would be no migraines to keep you up anymore. 

Final Verdict

Although these cannabis strains for migraines bring relief, everybody reacts differently when acquainted with a marijuana strain. In general, Indica or Indica-dominant strains with high levels of THC like Northern Lights and Purple Kush may help reduce chronic migraine pain as they are sedative and can induce sleep.

You won’t find this strain in each dispensary, but it should be on your list. ACDC is a strain that will instantly battle your migraine but won’t put you down and out. 

Make sure that you purchase cannabis strains from trustworthy dispensaries and companies so that you will have no issue with intensity and quality. 

Have you ever used cannabis or related products to help alleviate your headaches or migraines? Have you ever attempted any of these strains previously? Are there some other pain-relieving strains that you would add to the list? Then please give your comments below, and we would be happy to read your thoughts as well.

And yes, Before using cannabis to treat your migraines, make sure to consult with your doctor. 

The data listed, referenced, or connected to this website is for general instructive purposes and does not give professional medical or legal advice. We do not overlook, advocate, or advance illicit drug use. We are not responsible for any illegal drug use that our readers carry out. Please consult your doctor before using any products/methods listed in this article.


  • Cannabinoids for Migraine Prevention —
  • Effects of Medical Marijuana on Migraine—
  • Role of the Cannabinoid System in Pain Control—
  • Cannabinoid Receptors and the Endocannabinoid System—

Christopher Andrews
I am Christopher Andrew, the owner of 420 Expert Adviser. I have been in cannabis cultivation for more than ten years, and I'm sharing my experience with you guys using this blog!

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